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Fibronectin |
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| Cellular
Fibronectin is an
extracellular glycoprotein
that exists in a soluble form
in body fluids and in an
insoluble form in the
extracellular matrix. Its one
of the primary cell adhesion
molecules and plays a major
role in many important
physiological processes, such
as embryogenesis, wound
healing, hemostasis and
thrombosis. It is secreted as
a dimer with a monomer
molecular weight of 220–250
kDa. Altered fibronectin
expression, degradation, and
organization has been
associated with a number of
pathologies, including cancer
and fibrosis. It is
synthesized by, and present
around, fibroblasts,
endothelial cells,
chondrocytes, glial cells, and
myocytes. It represents an
active element in the process
of T cell activation in the
immune cascade triggered by
organ transplantation.
Different forms of fibronectin
appear to be generated from
tissue specific splicing of
fibronectin mRNA, transcribed
from a single gene. Multiple
domains show binding
affinities for collagen,
fibrin, heparin, and specific
cell membrane receptors. The
most notable domain,
Arg-Gly-Asp (RGD), is
recognized by integrins and
mediates cell adhesion.
Fibronectin is involved in
widespread interactions and
functions, such as the
attachment and migration of
many cell types, cytoskeletal
assembly, tyrosine
phosphorylation, and
metastasis. |
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| Model |
Product Name+ |
| 11-50-2101 |
Fibronectin [Bovine, in solution] |
| 11-50-1101 |
Fibronectin [Bovine, lyophilized] |
| 11-50-2102 |
Fibronectin [Hamster, in solution] |
| 11-50-1102 |
Fibronectin [Hamster, lyophilized] |
| 10-50-2101 |
Fibronectin [Human, in solution] |
| 10-50-1101 |
Fibronectin [Human, lyophilized] |
| 11-50-2105 |
Fibronectin [Mouse, in solution] |
| 11-50-1105 |
Fibronectin [Mouse, lyophilized] |
| 11-50-2103 |
Fibronectin [Rabbit, in solution] |
| 11-50-1103 |
Fibronectin [Rabbit, lyophilized] |
| 11-50-2104 |
Fibronectin [Rat, in solution] |
| 11-50-1104 |
Fibronectin [Rat, lyophilized] |
| 11-50-2106 |
Fibronectin [Salmon, in solution] |
| 11-50-1106 |
Fibronectin [Salmon, lyophilized] |
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