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Thrombin |
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| Thrombin
(activated Factor II [IIa]) is
a coagulation protein that has
many effects in the
coagulation cascade. It is a
serine protease (EC 3.4.21.5)
that converts soluble
fibrinogen into insoluble
strands of fibrin, as well as
catalyzing many other
coagulation-related reactions.
Due to its high proteolytic
specificity, thrombin is a
valuable biochemical tool. The
thrombin cleavage site
(Leu-Val-Pro-Arg-Gly-Ser) is
commonly included in linker
regions of recombinant fusion
protein constructs. Following
purification of the fusion
protein, thrombin can be used
to selectively cleave between
the Arginine and Glycine
residues of the cleavage site,
effectively removing the
purification tag from the
protein of interest with a
high degree of
specificity. |
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